ceesdekker No Further a Mystery

ceesdekker No Further a Mystery

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Employing single-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:

You regularly get entangled in discussions about science and religion. You've got also written various publications on the topic. Don’t you feel that at some point We are going to know every thing Which God’s position will probably be about?

Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

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Microbiology has only existed for a century, because we started to research micro-organisms a lot more significantly. I believed nanobiology was an acceptable expression, mainly because all molecular Organic suitable interactions occur in the nanoscale: a protein is several nanometres in measurement, DNA is 2 nm thick.’

‘To start with we checked out Organic methods by using a Actual physical view and acted on The https://www.ceesdekker.net idea with the tools we knew. It took a several years in advance of we began Doing work additional on the massive biological troubles. I then began to call it nanobiology, a phrase that did not exist at enough time.

2011, to start with in vitro measurements of transportation across one biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

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Really neat, but that wasn’t truly the place my desire lay. I desired to pioneer And that i experienced the sensation that was not doable, because the most exciting essential insights experienced currently been uncovered. But my discipline had designed lots of thrilling new equipment to evaluate unique molecules. I decided that I desired to implement this to biology, to have a look at it from the Actual physical point of view.’

Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments

Nature Physics many thanks the anonymous reviewers for his or her contribution on the peer evaluation of the perform.

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Illustration (2) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in grey, the rim of your pore is highlighted in crimson, in addition to a 3D rendering in the movement in the DNA rod is exhibited.